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HomeProduct name list5-TRANS FLUPROSTENOL

5-TRANS FLUPROSTENOL

5-TRANS FLUPROSTENOL Structural

What is 5-TRANS FLUPROSTENOL?

Description

Travoprost is the Alcon trade name for fluprostenol isopropyl ester, an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1 Fluprostenol isopropyl ester is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid, fluprostenol.2 5-trans Fluprostenol is an impurity that is routinely found in bulk preparations of fluprostenol in amounts ranging from 1-3%. This impurity occurs in the finished prodrug Travoprost in similar amounts. The pharmacology of 5-trans fluprostenol has not been studied extensively to date.

What are the applications of Application

5-trans Fluprostenol is a fluprostenol impurity

References

1. Hellberg, M.R., Sallee, V.L., McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist J. Ocul. Pharmacol. Ther. 17(5),421-432(2001).
2. Sorbera, L.A., and Casta?er, J. Travoprost Drugs Future 25(1),41-45(2000).

Properties of 5-TRANS FLUPROSTENOL

solubility  DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 15 mg/ml

Safety information for 5-TRANS FLUPROSTENOL

Computed Descriptors for 5-TRANS FLUPROSTENOL

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