5-THIO-D-GLUCOSE
- CAS NO.:20408-97-3
- Empirical Formula: C6H12O5S
- Molecular Weight: 196.22
- MDL number: MFCD00148892
- EINECS: 243-798-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 5-THIO-D-GLUCOSE?
Description
5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be used to induce a state of glucose deprivation in laboratory animals.2 Stimulates feeding in rat models.3? Induces Alzheimer-like changes in frontal cortex and hippocampus in rats.4? Elevates renal TGF-b1 at a dose that does not prevent streptozotocin diabetes in rats.5
The Uses of 5-THIO-D-GLUCOSE
5-Thio-D-glucose (cas# 20408-97-3) is a compound useful in organic synthesis.
What are the applications of Application
5-Thio-D-glucose is an inhibitor of the cellular transport of D-glucose and D-glucose mediated insulin release.
References
Wang et al. (1995) Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose; Clin. Endocrinol. Diabetes, 103 83 Suppl.2 Shah et al. (2019), Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus; J. Physiol. Endocrinol. Metab., 316 E948 Li et al. (2014), Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons; J. Physiol. Regul. Integr. Comp. Physiol., 306 R257 Salkovic-Petrisic et al. (2006), Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signaling pathway; J. Neurochem., 96 1005 Lane et al. (2000), 5-thio-D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozotocin diabetes in rats; Endocrinology, 141 3337
Properties of 5-THIO-D-GLUCOSE
Melting point: | 135-138 °C(lit.) |
Boiling point: | 303.11°C (rough estimate) |
Density | 1.271 (estimate) |
refractive index | 1.5060 (estimate) |
storage temp. | 2-8°C |
solubility | Soluble in Water (up to 15 mg/ml) |
form | Powder |
pka | 9.11±0.10(Predicted) |
color | White |
optical activity | [α]/D 220.0±5.0°, c = 1 in 0.1 M HCl |
Water Solubility | Miscible with water. |
Merck | 13,9408 |
BRN | 1865193 |
Stability: | Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. |
CAS DataBase Reference | 20408-97-3 |
EPA Substance Registry System | D-Glucose, 5-thio- (20408-97-3) |
Safety information for 5-THIO-D-GLUCOSE
Computed Descriptors for 5-THIO-D-GLUCOSE
New Products
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