2'-OMe-ibu-G Phosphoramidite

Synonym(s):DMT-2′-O-Me-rG(ib) amidite;N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-guanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS NO.：150780-67-9
Empirical Formula: C45H56N7O9P
Molecular Weight: 869.94
MDL number: MFCD16876397
EINECS: 2017-001-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is 2'-OMe-ibu-G Phosphoramidite?

The Uses of 2'-OMe-ibu-G Phosphoramidite

2''-OMe-ibu-G Phosphoramidite (CAS# 150780-67-9) is used in the synthesis of native-like crosslinked duplex RNA via interstrand crosslinking reaction between vinylpurine on one strand and target cytosine or uracil on the opposite strand.

Definition

2'-OMe-G(iBu)-3'-phosphoramidite is a chemically unstable and heat-sensitive nucleoside phosphoramidite that serves as a foundational element in oligonucleotide synthesis. 2'-OMe-RNA CE (β-cyanoethyl) Phosphoramidites are designed to produce synthetic oligonucleotides containing nuclease resistant 2'-O-methyl ribonucleotide linkages. Deprotection, isolation and handling of 2'-O-methyl oligonucleotides are identical to the procedures for oligodeoxynucleotides.

Properties of 2'-OMe-ibu-G Phosphoramidite

Melting point:	138 - 140°C
storage temp.	Inert atmosphere,2-8°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated)
form	powder
pka	9.16±0.20(Predicted)
color	white to off-white

Safety information for 2'-OMe-ibu-G Phosphoramidite

Computed Descriptors for 2'-OMe-ibu-G Phosphoramidite

InChIKey	IRRDHRZUOZNWDJ-MLLDKZSOSA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,44,47,r\|