5-NITROSO-8-HYDROXYQUINOLINE
- CAS NO.:3565-26-2
- Empirical Formula: C9H6N2O2
- Molecular Weight: 174.16
- MDL number: MFCD00041862
- EINECS: 222-650-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is 5-NITROSO-8-HYDROXYQUINOLINE?
Chemical properties
slightly yellow to yellow-green powder
The Uses of 5-NITROSO-8-HYDROXYQUINOLINE
5-NITROSO-8-HYDROXYQUINOLINE is shown to have cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells.
What are the applications of Application
NSC 3852 is an inhibitor of HDAC (histone deacetylase)
Definition
ChEBI: 5-nitroso-8-quinolinol is a hydroxyquinoline.
Biological Activity
Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo .
Safety Profile
Poison by intravenous and intraperitoneal routes. Many nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
storage
Room temperature
References
[1]. martirosyan a, leonard s, shi x, et al. actions of a histone deacetylase inhibitor nsc3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in mcf-7 human mammary tumor cells. j pharmacol exp ther, 2006, 317(2): 546-552.
[2]. strobl js, seibert cw, li y, et al. inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active antiproliferative and tumor cell differentiation agent. j parasitol, 2009, 95(1): 215-223.
Properties of 5-NITROSO-8-HYDROXYQUINOLINE
Melting point: | 245 °C |
Boiling point: | 305.12°C (rough estimate) |
Density | 1.40 |
refractive index | 1.5651 (estimate) |
storage temp. | Store at RT |
solubility | insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO |
form | solid |
color | Needles from EtOH |
CAS DataBase Reference | 3565-26-2(CAS DataBase Reference) |
EPA Substance Registry System | 8-Quinolinol, 5-nitroso- (3565-26-2) |
Safety information for 5-NITROSO-8-HYDROXYQUINOLINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-NITROSO-8-HYDROXYQUINOLINE
Abamectin manufacturer
Neugen Labs
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