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HomeProduct name list5-NITROSO-8-HYDROXYQUINOLINE

5-NITROSO-8-HYDROXYQUINOLINE

  • CAS NO.:3565-26-2
  • Empirical Formula: C9H6N2O2
  • Molecular Weight: 174.16
  • MDL number: MFCD00041862
  • EINECS: 222-650-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
5-NITROSO-8-HYDROXYQUINOLINE Structural

What is 5-NITROSO-8-HYDROXYQUINOLINE?

Chemical properties

slightly yellow to yellow-green powder

The Uses of 5-NITROSO-8-HYDROXYQUINOLINE

5-NITROSO-8-HYDROXYQUINOLINE is shown to have cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells.

What are the applications of Application

NSC 3852 is an inhibitor of HDAC (histone deacetylase)

Definition

ChEBI: 5-nitroso-8-quinolinol is a hydroxyquinoline.

Biological Activity

Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo .

Safety Profile

Poison by intravenous and intraperitoneal routes. Many nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

storage

Room temperature

References

[1]. martirosyan a, leonard s, shi x, et al. actions of a histone deacetylase inhibitor nsc3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in mcf-7 human mammary tumor cells. j pharmacol exp ther, 2006, 317(2): 546-552.
[2]. strobl js, seibert cw, li y, et al. inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active antiproliferative and tumor cell differentiation agent. j parasitol, 2009, 95(1): 215-223.

Properties of 5-NITROSO-8-HYDROXYQUINOLINE

Melting point: 245 °C
Boiling point: 305.12°C (rough estimate)
Density  1.40
refractive index  1.5651 (estimate)
storage temp.  Store at RT
solubility  insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO
form  solid
color  Needles from EtOH
CAS DataBase Reference 3565-26-2(CAS DataBase Reference)
EPA Substance Registry System 8-Quinolinol, 5-nitroso- (3565-26-2)

Safety information for 5-NITROSO-8-HYDROXYQUINOLINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-NITROSO-8-HYDROXYQUINOLINE

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