5-Nitrofluorescein
- CAS NO.:27402-68-2
- Empirical Formula: C20H11NO7
- Molecular Weight: 377.3
- MDL number: MFCD00059694
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-05 15:35:05
What is 5-Nitrofluorescein?
Chemical properties
Orange Cyrstalline Solid
The Uses of 5-Nitrofluorescein
Fluorescent labeling reagent for proteins, 6-Nitrofluorescein can be used in the fluorescent antibody technique for rapid identification of pathogens.
Preparation
5-Nitrofluorescein (3′,6′-dihydroxy-6-nitrospiro[2-benzofuran-3,9′-xanthene]-1-one) is a key intermediate in the synthesis of various fluorescent compounds such as 5-aminofluorescein (5-amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one), fluorescein 5-isothiocyanate (FITC; 3′,6′-dihydroxy-5-isothiocyanato-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one), and fluorescein lisicol (previously known as cholyl-lysylfluorescein or CLF.
Process for the preparation of 5-/6-nitrofluorescein(US20120220787A1)
Properties of 5-Nitrofluorescein
solubility | Acetone, Methanol |
form | Solid |
color | Orange Cyrstalline |
Stability: | Light and Moisture Sensitive |
InChI | InChI=1S/C20H11NO7/c22-11-2-5-14-17(8-11)27-18-9-12(23)3-6-15(18)20(14)16-7-10(21(25)26)1-4-13(16)19(24)28-20/h1-9,22-23H |
EPA Substance Registry System | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-6-nitro- (27402-68-2) |
Safety information for 5-Nitrofluorescein
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Nitrofluorescein
InChIKey | GYWGQAIDMYGOLU-UHFFFAOYSA-N |
SMILES | C12(C3=C(C=C(O)C=C3)OC3=C1C=CC(O)=C3)C1=C(C=CC([N+]([O-])=O)=C1)C(=O)O2 |
Related products of tetrahydrofuran
5-NITROFLUORESCEIN
4-Amino-2-methylbenzoic acid
2-Methyl-4-nitrobenzoic acid
ISOPROPYL 4-AMINOBENZOATE
N-Methyl-(2-thienylmethyl)amine
5-Nitro-1,3-dihydroisobenzofuran
(2-METHYL-5-NITROPHENYL)METHANOL
METHYL M-NITROPHENYL CARBINOL
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