5-Nitro-2-furoic acid
Synonym(s):5-Nitrofuran-2-carboxylic acid
- CAS NO.:645-12-5
- Empirical Formula: C5H3NO5
- Molecular Weight: 157.08
- MDL number: MFCD00003240
- EINECS: 211-432-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:34
What is 5-Nitro-2-furoic acid?
Chemical properties
yellow crystalline powder
The Uses of 5-Nitro-2-furoic acid
5-Nitro-2-furoic acid is a representative of 2-substituted 5-nitrofurans. A number of nitrofurans have been used as antibacterial, antiprotozoal, and anthelmintic drugs in humans and animals. 2-Substituted 5-nitrofurans have been used worldwide as human and veterinary medicines, food preservatives, and feed additives, and they are utilized in human medicine as antibacterial agents. Therefore, the relationship between the antibacterial effect and the mutagenicity of these compounds and their oxidized metabolites is important. Comparison of the antibacterial effects and genotoxic potencies of nitrofuran drugs and their oxidative metabolites may provide a new direction for selecting nitrofuran drugs for human use.
The Uses of 5-Nitro-2-furoic acid
5-Nitro-2-furoic acid was used in the preparation of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has also been studied.
General Description
The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has been studied.
Environmental Fate
5-Nitro-2-furoic acid is a yellow crystalline powder with molecular weight of 157.08 g mol-1 and density of 1.72 g cm-3. The boiling point is 332.4 ℃ and the melting point is 185.00– 189.00 ℃ at 760 mm Hg. Vapor pressure is 5.83E-05 mm Hg at 25 ℃ and enthalpy of vaporization is 60.71 kJ mol-1. 5-Nitro-2-furoic acid is very soluble in water. It is stable under normal temperature and pressure.
Toxicity evaluation
The toxicological properties of this compound have not been fully investigated. However, as a minimum precaution, it should be considered harmful. Precautions should be taken and procedures adopted to prevent exposure.
Properties of 5-Nitro-2-furoic acid
Melting point: | 185-189 °C (lit.) |
Boiling point: | 281.7°C (rough estimate) |
Density | 1.8109 (rough estimate) |
refractive index | 1.4798 (estimate) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 2.06±0.10(Predicted) |
color | White to Light Yellow |
Water Solubility | Slightly soluble in water. |
BRN | 139373 |
CAS DataBase Reference | 645-12-5(CAS DataBase Reference) |
NIST Chemistry Reference | 5-Nitrofuran-2-carboxylic acid(645-12-5) |
Safety information for 5-Nitro-2-furoic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. |
Computed Descriptors for 5-Nitro-2-furoic acid
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