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HomeProduct name list5-Nitro-2-furoic acid

5-Nitro-2-furoic acid

Synonym(s):5-Nitrofuran-2-carboxylic acid

  • CAS NO.:645-12-5
  • Empirical Formula: C5H3NO5
  • Molecular Weight: 157.08
  • MDL number: MFCD00003240
  • EINECS: 211-432-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 17:06:34
5-Nitro-2-furoic acid Structural

What is 5-Nitro-2-furoic acid?

Chemical properties

yellow crystalline powder

The Uses of 5-Nitro-2-furoic acid

5-Nitro-2-furoic acid is a representative of 2-substituted 5-nitrofurans. A number of nitrofurans have been used as antibacterial, antiprotozoal, and anthelmintic drugs in humans and animals. 2-Substituted 5-nitrofurans have been used worldwide as human and veterinary medicines, food preservatives, and feed additives, and they are utilized in human medicine as antibacterial agents. Therefore, the relationship between the antibacterial effect and the mutagenicity of these compounds and their oxidized metabolites is important. Comparison of the antibacterial effects and genotoxic potencies of nitrofuran drugs and their oxidative metabolites may provide a new direction for selecting nitrofuran drugs for human use.

The Uses of 5-Nitro-2-furoic acid

5-Nitro-2-furoic acid was used in the preparation of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has also been studied.

General Description

The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has been studied.

Environmental Fate

5-Nitro-2-furoic acid is a yellow crystalline powder with molecular weight of 157.08 g mol-1 and density of 1.72 g cm-3. The boiling point is 332.4 ℃ and the melting point is 185.00– 189.00 ℃ at 760 mm Hg. Vapor pressure is 5.83E-05 mm Hg at 25 ℃ and enthalpy of vaporization is 60.71 kJ mol-1. 5-Nitro-2-furoic acid is very soluble in water. It is stable under normal temperature and pressure.

Toxicity evaluation

The toxicological properties of this compound have not been fully investigated. However, as a minimum precaution, it should be considered harmful. Precautions should be taken and procedures adopted to prevent exposure.

Properties of 5-Nitro-2-furoic acid

Melting point: 185-189 °C (lit.)
Boiling point: 281.7°C (rough estimate)
Density  1.8109 (rough estimate)
refractive index  1.4798 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 2.06±0.10(Predicted)
color  White to Light Yellow
Water Solubility  Slightly soluble in water.
BRN  139373
CAS DataBase Reference 645-12-5(CAS DataBase Reference)
NIST Chemistry Reference 5-Nitrofuran-2-carboxylic acid(645-12-5)

Safety information for 5-Nitro-2-furoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H319:Serious eye damage/eye irritation
H341:Germ cell mutagenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.

Computed Descriptors for 5-Nitro-2-furoic acid

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