5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
- CAS NO.:64273-28-5
- Empirical Formula: C9H8N2S
- Molecular Weight: 176.24
- MDL number: MFCD00100201
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE?
The Uses of 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
4-phenyl-5-methyl-1,2,3-Thiadiazole is a selective, mechanism-based inhibitor of CYP2B4 and CYP2E1.
What are the applications of Application
4-phenyl-5-methyl-1,2,3-Thiadiazole is a selective, mechanism-based inhibitor of CYP2B4 and CYP2E1
Biological Activity
4-phenyl-5-methyl-1,2,3-thiadiazole is a cyp2b4 and cyp2e1 inhibitor.cytochrome p450 (cyp450) enzymes, a superfamily of oxidative catalysts, are important in the biosynthesis and metabolism of a wide range of endogenous molecules and the metabolism of xenobiotics. cyp2b4 can metabolize substituted amines, while cyp2e1 metabolizes various alcohols and halogenated alkenes.
in vitro
4-phenyl-5-methyl-1,2,3-thiadiazole (pmt) was found to be slightly more inhibitory to p450s 2e1 and 1a2 than its close analog, 4,5-diphenyl-1,2,3-thiadiazole (dpt). by contrast, 4-phenyl-5-hydrogen-1,2,3-thiadiazole (pt), a weaker inhibitor than dpt and pmt with p450s 2e1 and 2b4, was comparable to pmt and more effective than dpt with p450 1a2. moreover, pmt, dpt, as well as pt showed no inactivation of either p450 2e1 or 2b4, though they were fairly effective inhibitors, and the thiadiazole ring could be oxidized by the p450 system. furthremore, the lack of inactivation of the p450 isoforms by pmt, dpt, and pt suggested that a transient reactive intermediate was not formed on oxidation of the thiadiazole ring. in additioin, the 1,2,3-thiadiazole ring could be oxidized by the p450 system [1].
References
[1] babu, b. r. and vaz, a.d.n. 1,2,3-thiadiazole: a novel heterocyclic heme ligand for the design of cytochrome p450 inhibitors. biochemistry 36, 7209-7216 (1997).
Properties of 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
storage temp. | Store at -20°C |
solubility | insoluble in H2O; ≥10.38 mg/mL in EtOH; ≥7.85 mg/mL in DMSO |
color | Red-brown |
Safety information for 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B 2,2-diethoxyethanethioamide Tubulysin B Tubulysin D Tubulysin M Tubulysin A 5-Methoxy pyridine-2-methanol 6-chloro-4-methylnicotinonitrile S(-)3-Amino tetrahydrofuran 3-Methyl pyridine-4-carboxylicacid 2,6-dichloro-3-nitropyridin-4-amine 4-(Chloromethyl)-7-Hydroxy-2H-chromen-2-one (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Fuel shell 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 5-AminophthalazineRelated products of tetrahydrofuran
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