5-METHOXYFLAVONE

CAS NO.：42079-78-7
Empirical Formula: C16H12O3
Molecular Weight: 252.26
MDL number: MFCD00016942
EINECS: 255-652-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-17 16:00:36

What is 5-METHOXYFLAVONE?

The Uses of 5-METHOXYFLAVONE

5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.

Definition

ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.

Biological Activity

5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.

in vitro

5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.

in vivo

5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.

Properties of 5-METHOXYFLAVONE

Melting point:	131-133°C
Boiling point:	422.5±45.0 °C(Predicted)
Density	1,155g/cm
refractive index	1,548
storage temp.	Store at -20°C
solubility	soluble in Methanol
form	powder to crystal
color	White to Almost white
CAS DataBase Reference	42079-78-7(CAS DataBase Reference)

Safety information for 5-METHOXYFLAVONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.