5-METHOXYFLAVONE
- CAS NO.:42079-78-7
- Empirical Formula: C16H12O3
- Molecular Weight: 252.26
- MDL number: MFCD00016942
- EINECS: 255-652-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-23 09:40:05
What is 5-METHOXYFLAVONE?
The Uses of 5-METHOXYFLAVONE
5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.
Definition
ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.
Biological Activity
5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.
in vitro
5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.
in vivo
5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.
Properties of 5-METHOXYFLAVONE
Melting point: | 131-133°C |
Boiling point: | 422.5±45.0 °C(Predicted) |
Density | 1,155g/cm |
refractive index | 1,548 |
storage temp. | Store at -20°C |
solubility | soluble in Methanol |
form | powder to crystal |
color | White to Almost white |
CAS DataBase Reference | 42079-78-7(CAS DataBase Reference) |
Safety information for 5-METHOXYFLAVONE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 5-METHOXYFLAVONE
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