5-METHOXYINDOLE-2-CARBOXYLIC ACID
Synonym(s):NSC 30927
- CAS NO.：4382-54-1
- Empirical Formula: C10H9NO3
- Molecular Weight: 191.18
- MDL number: MFCD00005614
- EINECS: 224-487-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:38
What is 5-METHOXYINDOLE-2-CARBOXYLIC ACID?
Chemical properties
LIGHT YELLOW TO BROWNISH POWDER
The Uses of 5-METHOXYINDOLE-2-CARBOXYLIC ACID
5-Methoxyindole-2-carboxylic Acid is a very useful synthetic intermediate. It is a reactant used to prepare anticancer agents, Indoleamine 2,3-dioxygenase (IDO) inhibitors, and potent antitumor bifunctional DNA alkylating agents.
The Uses of 5-METHOXYINDOLE-2-CARBOXYLIC ACID
Reactant for preparation of:• ;Anticancer agents1• ;A fluorescent small molecule probe for in vivo lipid imaging2• ;Indoleamine 2,3-dioxygenase (IDO) inhibitors3• ;Selective Dopamine D3 receptor ligands4• ;5-HT4 receptor ligands5• ;Inhibitors of Mycobacterium tuberculosis pantothenate synthetase6• ;Hypoxia selective cytotoxins7• ;Potent antitumor bifunctional DNA alkylating agents8
The Uses of 5-METHOXYINDOLE-2-CARBOXYLIC ACID
Reactant for preparation of:
- Anticancer agents
- A fluorescent small molecule probe for in vivo lipid imaging
- Indoleamine 2,3-dioxygenase (IDO) inhibitors
- Selective Dopamine D3 receptor ligands
- 5-HT4 receptor ligands
- Inhibitors of Mycobacterium tuberculosis pantothenate synthetase
- Hypoxia selective cytotoxins
- Potent antitumor bifunctional DNA alkylating agents
What are the applications of Application
5-Methoxyindole-2-carboxylic acid is A reactant for the preparation of anticancer agents and multiple inhibitors
Definition
ChEBI: 5-methoxyindole-2-carboxylic acid is an indolecarboxylic acid that is indole-2-carboxylic acid carrying an additional methoxy substituent at position 5. It has a role as a plant metabolite, a hypoglycemic agent and an EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor. It is an indolecarboxylic acid and an aromatic ether.
Properties of 5-METHOXYINDOLE-2-CARBOXYLIC ACID
| Melting point: | 199-201 °C (lit.) |
| Boiling point: | 326.92°C (rough estimate) |
| Density | 1.2722 (rough estimate) |
| refractive index | 1.5310 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Powder |
| pka | 4.38±0.30(Predicted) |
| color | Light yellow to brownish |
| BRN | 157478 |
| CAS DataBase Reference | 4382-54-1(CAS DataBase Reference) |
Safety information for 5-METHOXYINDOLE-2-CARBOXYLIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-METHOXYINDOLE-2-CARBOXYLIC ACID
| InChIKey | YEBJVSLNUMZXRJ-UHFFFAOYSA-N |
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