5-METHOXYINDOLE-2-CARBOXYLIC ACID

Synonym(s):NSC 30927

CAS NO.：4382-54-1
Empirical Formula: C10H9NO3
Molecular Weight: 191.18
MDL number: MFCD00005614
EINECS: 224-487-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:13:47

5-METHOXYINDOLE-2-CARBOXYLIC ACID Structural

What is 5-METHOXYINDOLE-2-CARBOXYLIC ACID?

Chemical properties

LIGHT YELLOW TO BROWNISH POWDER

The Uses of 5-METHOXYINDOLE-2-CARBOXYLIC ACID

5-Methoxyindole-2-carboxylic Acid is a very useful synthetic intermediate. It is a reactant used to prepare anticancer agents, Indoleamine 2,3-dioxygenase (IDO) inhibitors, and potent antitumor bifunctional DNA alkylating agents.

The Uses of 5-METHOXYINDOLE-2-CARBOXYLIC ACID

Reactant for preparation of:• ;Anticancer agents1• ;A fluorescent small molecule probe for in vivo lipid imaging2• ;Indoleamine 2,3-dioxygenase (IDO) inhibitors3• ;Selective Dopamine D3 receptor ligands4• ;5-HT4 receptor ligands5• ;Inhibitors of Mycobacterium tuberculosis pantothenate synthetase6• ;Hypoxia selective cytotoxins7• ;Potent antitumor bifunctional DNA alkylating agents8

The Uses of 5-METHOXYINDOLE-2-CARBOXYLIC ACID

Reactant for preparation of:

Anticancer agents
A fluorescent small molecule probe for in vivo lipid imaging
Indoleamine 2,3-dioxygenase (IDO) inhibitors
Selective Dopamine D3 receptor ligands
5-HT4 receptor ligands
Inhibitors of Mycobacterium tuberculosis pantothenate synthetase
Hypoxia selective cytotoxins
Potent antitumor bifunctional DNA alkylating agents

What are the applications of Application

5-Methoxyindole-2-carboxylic acid is A reactant for the preparation of anticancer agents and multiple inhibitors

Definition

ChEBI: 5-methoxyindole-2-carboxylic acid is an indolecarboxylic acid that is indole-2-carboxylic acid carrying an additional methoxy substituent at position 5. It has a role as a plant metabolite, a hypoglycemic agent and an EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor. It is an indolecarboxylic acid and an aromatic ether.

Properties of 5-METHOXYINDOLE-2-CARBOXYLIC ACID

Melting point:	199-201 °C (lit.)
Boiling point:	326.92°C (rough estimate)
Density	1.2722 (rough estimate)
refractive index	1.5310 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder
pka	4.38±0.30(Predicted)
color	Light yellow to brownish
BRN	157478
CAS DataBase Reference	4382-54-1(CAS DataBase Reference)

Safety information for 5-METHOXYINDOLE-2-CARBOXYLIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.