5-Fluoroisatonic anhydride
- CAS NO.：321-69-7
- Empirical Formula: C8H4FNO3
- Molecular Weight: 181.12
- MDL number: MFCD03300719
- EINECS: 640-488-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:25
What is 5-Fluoroisatonic anhydride?
Chemical properties
Dark yellow Solid
The Uses of 5-Fluoroisatonic anhydride
5-Fluoroisatoic Anhydride is a versatile pharmaceutical intermediate used in the preparation of insulin secretagogues, HCV polymerase inhibitors, anxiolytic agents and other bioactive compounds.
Preparation
5-Fluoroisatonic anhydride is prepared from 5-fluoro indole (9d) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1 H NMR (DMSO-d6): δ11.19 (s, br., 1H), 7.36 (dd, J = 8.4, 2.6 Hz, 1H), 6.87 (dt, J = 8.4, 2.2 Hz, 1H), 6.74 (dd, J = 9.3, 2.2 Hz, 1H).
Properties of 5-Fluoroisatonic anhydride
| Melting point: | 259-262°C |
| Density | 1.502±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in DMSO |
| pka | 9.61±0.20(Predicted) |
| color | Off-white to pale yellow |
| CAS DataBase Reference | 321-69-7(CAS DataBase Reference) |
Safety information for 5-Fluoroisatonic anhydride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 5-Fluoroisatonic anhydride
New Products
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