5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE
- CAS NO.：158848-32-9
- Empirical Formula: C23H27FN2O2S
- Molecular Weight: 414.54
- MDL number: MFCD05665140
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
![5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE Structural](https://img.chemicalbook.in/CAS/GIF/158848-32-9.gif)
What is 5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE?
The Uses of 5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE
GR 159897 is an NK2 receptor antagonist which aids in the treatment of IBS.
What are the applications of Application
GR 159897 is a compound that acts as an effective and selective NK2 receptor antagonist
Biological Activity
A potent, selective, non-peptide, orally active neurokinin NK 2 receptor antagonist. Competes for binding of [ 3 H]GR100679 to hNK 2 -transfected CHO cells with a pK i of 9.5. Inhibits NK 2 receptor-mediated contraction of guinea pig trachea with a pA 2 of 8.7. Anxiolytic in vivo .
storage
Desiccate at -20°C
Properties of 5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE
| Boiling point: | 600.2±55.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: ~24 mg/mL, soluble |
| form | solid |
| pka | 16.46±0.30(Predicted) |
| color | off-white |
Safety information for 5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE
Computed Descriptors for 5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE
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