5-Fluoro-2-picolinic acid
- CAS NO.：107504-08-5
- Empirical Formula: C6H4FNO2
- Molecular Weight: 141.1
- MDL number: MFCD04114196
- EINECS: 675-772-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-04 16:41:33
What is 5-Fluoro-2-picolinic acid?
Synthesis
Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%). 
Properties of 5-Fluoro-2-picolinic acid
| Melting point: | 164-166℃ |
| Boiling point: | 275.1±20.0 °C(Predicted) |
| Density | 1.419±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 3.58±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| CAS DataBase Reference | 107504-08-5(CAS DataBase Reference) |
Safety information for 5-Fluoro-2-picolinic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 5-Fluoro-2-picolinic acid
| InChIKey | JTKFIIQGMVKDNZ-UHFFFAOYSA-N |
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