5-FLUORO-1,3-DIMETHYLURACIL
Synonym(s):1,3-Dimethyl-5-fluorouracil;2,4-Dihydroxy-1,3-dimethyl-5-fluoropyrimidine
- CAS NO.:3013-92-1
- Empirical Formula: C6H7FN2O2
- Molecular Weight: 158.13
- MDL number: MFCD00192176
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-09 08:28:05
What is 5-FLUORO-1,3-DIMETHYLURACIL?
The Uses of 5-FLUORO-1,3-DIMETHYLURACIL
5-Fluoro-1,3-dimethyluracil may be used as starting material in the following processes:
- Regioselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones.
- To synthesize 5-bis(ethoxycarbonyl)methyl-1,3-dimethyluracil.
- To synthesize new highly conjugated propenylidene derivatives via aromatic Paterno-Buchi type cycloaddition with 1-methoxynaphthalene.
Synthesis Reference(s)
Tetrahedron, 46, p. 3093, 1990 DOI: 10.1016/S0040-4020(01)88400-3
General Description
Oxidation of 5-fluoro-1,3-dimethyluracil (5-FDMU) with m-chloroperbenzoic acid has been described. It is reported as antineoplastic drug. On photoirradiation, 5-fluoro-1,3-dimethyluracil yields the trans-anti cyclobutane dimer and the cis-syn cyclobutane dimer. UV irradiation of 5-FDMU and naphthalene in a protic medium affords 5-(1-naphthyl)uracil, while in aprotic media it undergoes stereoselective 1,4-cycloaddition reaction to give a barrelene derivative. The thermochemical parameters of 5-FDMU has been determined. It reacts with substituted benzenes in the presence of trifluoroacetic acid to generate 5-aryl-1,3-dimethyluracils via photosubstitution.
Properties of 5-FLUORO-1,3-DIMETHYLURACIL
Melting point: | 132-134 °C(lit.) |
Boiling point: | 182.5±50.0 °C(Predicted) |
Density | 1.37±0.1 g/cm3(Predicted) |
pka | -4.07±0.40(Predicted) |
BRN | 880396 |
Safety information for 5-FLUORO-1,3-DIMETHYLURACIL
Computed Descriptors for 5-FLUORO-1,3-DIMETHYLURACIL
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) VILDAGLIPTIN ACICLOVIR AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE Desloratidine Related compound B Folic Acid Impurity G Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
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