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HomeProduct name list5-FLUORO-1,3-DIMETHYLURACIL

5-FLUORO-1,3-DIMETHYLURACIL

Synonym(s):1,3-Dimethyl-5-fluorouracil;2,4-Dihydroxy-1,3-dimethyl-5-fluoropyrimidine

5-FLUORO-1,3-DIMETHYLURACIL Structural

What is 5-FLUORO-1,3-DIMETHYLURACIL?

The Uses of 5-FLUORO-1,3-DIMETHYLURACIL

5-Fluoro-1,3-dimethyluracil may be used as starting material in the following processes:

  • Regioselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones.
  • To synthesize 5-bis(ethoxycarbonyl)methyl-1,3-dimethyluracil.
  • To synthesize new highly conjugated propenylidene derivatives via aromatic Paterno-Buchi type cycloaddition with 1-methoxynaphthalene.

Synthesis Reference(s)

Tetrahedron, 46, p. 3093, 1990 DOI: 10.1016/S0040-4020(01)88400-3

General Description

Oxidation of 5-fluoro-1,3-dimethyluracil (5-FDMU) with m-chloroperbenzoic acid has been described. It is reported as antineoplastic drug. On photoirradiation, 5-fluoro-1,3-dimethyluracil yields the trans-anti cyclobutane dimer and the cis-syn cyclobutane dimer. UV irradiation of 5-FDMU and naphthalene in a protic medium affords 5-(1-naphthyl)uracil, while in aprotic media it undergoes stereoselective 1,4-cycloaddition reaction to give a barrelene derivative. The thermochemical parameters of 5-FDMU has been determined. It reacts with substituted benzenes in the presence of trifluoroacetic acid to generate 5-aryl-1,3-dimethyluracils via photosubstitution.

Properties of 5-FLUORO-1,3-DIMETHYLURACIL

Melting point: 132-134 °C(lit.)
Boiling point: 182.5±50.0 °C(Predicted)
Density  1.37±0.1 g/cm3(Predicted)
pka -4.07±0.40(Predicted)
BRN  880396

Safety information for 5-FLUORO-1,3-DIMETHYLURACIL

Computed Descriptors for 5-FLUORO-1,3-DIMETHYLURACIL

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