5-Chlorosalicylaldehyde

CAS NO.：635-93-8
Empirical Formula: C7H5ClO2
Molecular Weight: 156.57
MDL number: MFCD00003331
EINECS: 211-244-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is 5-Chlorosalicylaldehyde?

Chemical properties

white to very slightly yellow crystalline powder

The Uses of 5-Chlorosalicylaldehyde

5-Chlorosalicyaldehyde is a useful synthetic intermediate and a key precursor to a variety chelating agents.5-Chlorosalicyaldehyde is used to synthesize imine resveratrol (R150000) derivatives as multi-targeted agents against Alzheimer's disease.

Synthesis Reference(s)

Synthetic Communications, 20, p. 609, 1990 DOI: 10.1080/00397919008244911
Tetrahedron Letters, 15, p. 3463, 1974

Purification Methods

Steam distil it, then crystallise it from aqueous EtOH or *C6H6 (m 100o). It forms complexes with Cu2+ and Fe2+ . [Beilstein 8 H 53, 8 II 45, 8 III 181, 8 IV 224.]

Properties of 5-Chlorosalicylaldehyde

Melting point:	100-102 °C(lit.)
Boiling point:	217.69°C (rough estimate)
Density	1.2683 (rough estimate)
refractive index	1.5812 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Crystalline Powder
pka	7.73±0.18(Predicted)
color	White to very slightly yellow
Sensitive	Air Sensitive
BRN	636632
CAS DataBase Reference	635-93-8(CAS DataBase Reference)
NIST Chemistry Reference	5-Chloro-2-hydroxy benzaldehyde(635-93-8)
EPA Substance Registry System	Benzaldehyde, 5-chloro-2-hydroxy- (635-93-8)

Safety information for 5-Chlorosalicylaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.