5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE

CAS NO.：28480-70-8
Empirical Formula: C9H9ClO2
Molecular Weight: 184.62
MDL number: MFCD00191920
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:34

What is 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE?

The Uses of 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE

5′-Chloro-2′-hydroxy-4′-methylacetophenone (5-chloro-2-hydroxy-4-methylacetophenone) may be used in the preparation of the following:

chalcones, required for the synthesis of novel pyrazoline derivatives
5′-chloro-2′-hydroxy-4′-methyl-3-(2′′-thienyl)acrylophenone
6-chloro-3-hydroxy-7-methyl-2-(2-thienyl)-4H-chromen-4-one, a complexing agent used for the spectrophotometric determination of vanadium(V)

Preparation

Preparation by reaction of acetic acid on 4-chloro-3- methylphenol with boron trifluoride at 70–100° (80–85%).

General Description

5′-chloro-2′-hydroxy-4′-methylacetophenone (5-Chloro-2-hydroxy-4-methylacetophenone) is a hydroxylated aromatic acetophenone. Its iodination by pyridinium iodochloride has been reported to afford 5-chloro-2-hydroxy-3-iodo-4-methylacetophenone.

Properties of 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE

Melting point:	70-73 °C(lit.)
Boiling point:	137 °C / 15mmHg
Density	1.250±0.06 g/cm3(Predicted)
form	powder to crystal
pka	9.84±0.23(Predicted)
color	White to Light yellow
CAS DataBase Reference	28480-70-8(CAS DataBase Reference)

Safety information for 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.