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HomeProduct name list5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

Synonym(s):5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid

5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Structural

What is 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID?

The Uses of 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs.

What are the applications of Application

nTZDpa is a non-thiazolidinedione PPARγ partial agonist

Biological Activity

Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .

storage

Store at +4°C

Properties of 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

storage temp.  Store at +4°C
solubility  DMSO: soluble15mg/mL, clear
form  powder
color  white to beige

Safety information for 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

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