5-Bromothiazole

CAS NO.：3034-55-7
Empirical Formula: C3H2BrNS
Molecular Weight: 164.02
MDL number: MFCD07787394
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-18 18:48:51

What is 5-Bromothiazole?

The Uses of 5-Bromothiazole

5-Bromothiazole is used as a pharmaceutical intermediate and performance material.

General Description

5-Bromothiazole is a monobromothiazole, which can be prepared via treatment of 2,5-dibromothiazole with sodium ethoxide followed by hydrogenation over spongy nickel.

Purification Methods

If bromothiazole is too coloured, then suspend it in dilute NaOH and steam distil it. Add NaCl to the aqueous distillate, extract it with Et2O, dry it (Na2SO4), evaporate and fractionate the residue in a vacuum. The HgCl2 salt crystallises from EtOH with m 148o (dec). [Beyerman et al. Recl Trav Chim, Pays Bas 73 330 1954, Beilstein 27 III/IV 962.]

Properties of 5-Bromothiazole

Melting point:	131-132 °C(Solv: ligroine (8032-32-4))
Boiling point:	80-81°C/18mm
Density	1.835 at 25 °C
refractive index	1.5955
Flash point:	170°F
form	Liquid
pka	1.00±0.10(Predicted)
color	Clear yellow to brown
Water Solubility	Soluble in water.
Sensitive	Moisture Sensitive
CAS DataBase Reference	3034-55-7(CAS DataBase Reference)

Safety information for 5-Bromothiazole

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.