5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Synonym(s):5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

CAS NO.：22276-95-5
Empirical Formula: C6H3BrClN3
Molecular Weight: 232.47
MDL number: MFCD09702029
EINECS: 622-419-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-16 09:53:33

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Structural

What is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine?

The Uses of 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) was dissolved in 75 mL of chloroform, followed by added 3.5 g (0.02 mol) of N-bromosuccinamide. The resulting mixture was refluxed for 1 h. After cooling to room temperature, the precipitate was removed by filtration and dried under reduced pressure to afford 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine.

Properties of 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Melting point:	221-225℃
Boiling point:	221.0±50.0 °C(Predicted)
Density	2.15±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	9.43±0.20(Predicted)
color	Yellow
Water Solubility	Slightly soluble in water.
CAS DataBase Reference	22276-95-5

Safety information for 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.