5-Benzyloxytryptophan
- CAS NO.:1956-25-8
- Empirical Formula: C18H18N2O3
- Molecular Weight: 310.35
- MDL number: MFCD09033126
- EINECS: 217-798-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:35
What is 5-Benzyloxytryptophan?
Manufacturing Process
Preparation of 5-Benzyloxytryptophan: 11 grams α-acetylamino-β-(5- benzyloxy-indolyl-3)-propionic acid was suspended in a solution of 12 grams sodium hydroxide in 90 ml water and refluxed for 24 hours. Charcoal was added to the resultant solution and the mixture filtered hot. 150 ml 2N hydrochloric acid was added to the filtrate at 70°C and 5-benzyloxytryptophan crystallized on cooling. After washing with water and drying in vacuo over silica gel, the amino acid (6.9 grams, 71%) had MP (sealed evacuated tube) 232°C, with softening, finally melting at 237° to 238°C (decomposition). Charcoal was added to the filtrate, which was filtered hot and adjusted to pH 2. On cooling a second crop of 5-benzyloxytryptophan was obtained (2.2 grams, 23%), MP (sealed evacuated tube) 230°C, with softening, finally melting at 233° to 237°C (decomposition). The overall yield of 5- benzyloxytryptophan was 9.1 grams (94%).
Properties of 5-Benzyloxytryptophan
Melting point: | 275-276 °C (decomp) |
Boiling point: | 563.4±50.0 °C(Predicted) |
Density | 1.323±0.06 g/cm3(Predicted) |
form | powder to crystal |
pka | 2.22±0.10(Predicted) |
color | White to Light yellow to Light red |
Safety information for 5-Benzyloxytryptophan
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 5-Benzyloxytryptophan
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