5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS NO.:475488-23-4
- Empirical Formula: C28H31N5O
- Molecular Weight: 453.58
- MDL number: MFCD16038913
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:03
What is 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine?
The Uses of 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
NVP-ADW742 is an IGF-1R inhibitor with IC50?of 0.17 μM.
What are the applications of Application
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM
Biological Activity
nvp-adw742 is a novel inhibitor of ifg-1receptor (igf-1r) kinase with the ic50 value of 0.17μm [1].nvp-adw742 has shown above 16-fold effective function against igf-1r than insulin receptor (insr). furthermore, nvp-adw742 has also been reported to inhibit other kinases , with the ic50 values of >10μm for her2, pdgfr, vegfr-2, or bcr-abl p210, and the ic50 values >5μm for c-kit [1]. besides, nvp-adw742 combined with etoposide and carboplatin has been reported to inhibit cell growth and induce cytotoxicity by mtt assay using the small cell lung cancer (sclc), including h526, h146, wba and h209 cell lines. in addition, nvp-adw742 has been revealed to completely inhibit the expression of vegf mrna which induced by igf-i in h526 cells [2].
storage
Store at -20°C
References
[1] mitsiades cs1, mitsiades ns, mcmullan cj, poulaki v, shringarpure r, akiyama m, hideshima t, chauhan d, joseph m, libermann ta, garcía-echeverría c, pearson ma, hofmann f, anderson kc, kung al. inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors . cancer cell. 2004 mar; 5(3):221-30.
[2]warshamana-greene gs1, litz j, buchdunger e, garcía-echeverría c, hofmann f, krystal gw. the insulin-like growth factor-i receptor kinase inhibitor, nvp-adw742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. clin cancer res. 2005 feb 15;11(4):1563-71.
Properties of 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Boiling point: | 677.5±55.0 °C(Predicted) |
Density | 1.31 |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | crystalline solid |
pka | 10.00±0.20(Predicted) |
color | White to light yellow |
Safety information for 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin G (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin M Tubulysin F 2,2-diethoxyethanethioamide (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Fuel shell Imeglimin Hydrochloride IH 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine 1-(4-Chlorophenyl)piperidin-2-one Diethyl 2,5-di(furan-2-yl)terephthalate 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4,8-dibromo-5H-[1,2,3]triazolo[4',5':4,5]benzo[1,2-c][1,2,5]thiadiazole 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 2,2-dibromopropanoate (±)-1-Phenylethane ethane sulfonic acidRelated products of tetrahydrofuran
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