5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
- CAS NO.:173140-90-4
- Empirical Formula: C18H15NO3
- Molecular Weight: 293.32
- MDL number: MFCD17018704
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-06 16:47:05
What is 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone?
The Uses of 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
A 5 liter flask equipped with a mechanical stirrer, thermometer, and refluxing condenser was charged with 8-benzyloxy-5-[(R)-(2-bromo-1-hydroxyethyl)]-carbostyriI (70gms/0.187 moles), potassium carbonate (74 gmsl 0.536 moles), acetone (3.5 liters) and water (35 ml). The resulting slurry 'was heated to reflux and maintained for 2% hours. After completion of reaction, the hot mass was filtered on hylo bed to remove inorganics. The residue was slurried in dichloromethane (200 ml) and filtered on hyflo bed. The filtrates were combined together and concentrated under vacuum completely. The residue was dissolved. in dichloromethane (500ml) and filtered on hyflo bed to remove traces of insolubles and washed with dichloromethane(100 ml). The clear filtrate was distilled completely to obtain residue. The residue was charged with methanol (70 ml), stirred and heated to 50??C for 30 minutes. The slurry obtained was cooled to 25-30??C,chilled to 0- 5??C, stirred for 1 hour. The resulting solid was isolated by filtration, washed with methanol (30ml), followed by diisopropylether (100ml) and dried under vacuum at 60-65 ??C for 10-12 hours to yield 40-41 gms of 8-benzyloxy- 5-(R)-oxiranylcarbostyril.
Properties of 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
Melting point: | 155 - 157°C |
Boiling point: | 556.0±50.0 °C(Predicted) |
Density | 1.298 |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 10.92±0.70(Predicted) |
color | White to Pale Yellow |
Stability: | Hygroscopic |
Safety information for 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
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