4SC-201
- CAS NO.:864814-88-0
- Empirical Formula: C16H19N3O4S
- Molecular Weight: 349.4
- MDL number: MFCD18633257
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is 4SC-201?
The Uses of 4SC-201
Resminostat is an oral histone deacetylase (HDAC) inhibitor. It inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells.
Biological Activity
resminostat, also known as ras2410, is a potent inhibitor of histone deacetylase (hdac) classes i and ii (including hdac1, hdac3 and hdac6) with 50% inhibition concentration ic50 values ranging from 43 to 72 nmol/l. resminostate has the potential to be used for the treatment of multiple myeloma (mm) due to its ability to induce histone h4 hyperacetylation, and apoptosis (ic50 ranging from 2.5 to 3 μmol/l) in mm cells. recent study results have shown that, in mm cell lines, resminostat abrogates cell growth, suppresses proliferation and induce g0/g1 cell cycle arrest as well as interfering with akt signaling pathway by decreasing phosphorylation of 4e-bp1 and p70s6k.mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010; 149(4):518-528.
Properties of 4SC-201
Density | 1.28±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | Powder |
pka | 8.68±0.23(Predicted) |
Safety information for 4SC-201
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4SC-201
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Rimegepant Impurity 3 Ivermectin EP Impurity B Fosfomycin EP impurity D Tubulysin M Tubulysin F Imeglimin Hydrochloride IH Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Methyl 4-amino-3-(piperidin-1-yl)benzoate 4-(Azidomethyl)-3-chloropyridine 2-Ethoxy-4-nitrobenzoic acid 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (4-(1-Hydroxycyclobutyl)phenyl)boronic acid pinacol ester 4-BROMO-5-FLUORONAPHTHALEN-2-OL Ethyl (2Z)-chloro((4-methoxyphenyl)hydrazono)acetate tert-butyl2-amino-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate 4-fluoro-1-methyl-pyrazoleRelated products of tetrahydrofuran
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