(4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
- CAS NO.：86286-50-2
- Empirical Formula: C15H13NO2
- Molecular Weight: 239.27
- MDL number: MFCD00674023
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-08-15 17:37:21
What is (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE?
Chemical properties
White powder or crystal
The Uses of (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
Versatile chiral auxiliary for asymmetric synthesis. For a recent review, see Aldrichimica Acta .
Preparation
To a stirred suspension of commercially available (10.0 g, 47 mmol) and triethylamine (14.4 mL, 0.10 mol) in dichloromethane (100 mL), diphosgene (3.0 mL, 25 mmol) was added dropwise at 0 °C and the mixture was stirred for 1 h at the same temperature. After concentration in vacuo, the residue was poured into water to precipitate crystals. The crystals were collected by filtration, successively washed with 10% HCl and H2O, and dried in vacuo at 50–60 °C for 3 h to afford 593a as colorless crystals (10.9 g, 97%).
Properties of (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
| Melting point: | 227-230 °C (lit.) |
| Boiling point: | 466.6±45.0 °C(Predicted) |
| Density | 1.192±0.06 g/cm3(Predicted) |
| pka | 11.56±0.60(Predicted) |
| optical activity | [α]20/D 57±4°, c = 2 in methanol |
Safety information for (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
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