(4R)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID
- CAS NO.:65705-83-1
- Empirical Formula: C19H32N2O5
- Molecular Weight: 368.47
- MDL number: MFCD01632735
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is (4R)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID?
What are the applications of Application
BW 246C is the less active C-8 diastereomer of the DP receptor agonist BW 245C
Biological Activity
bw 246c is a dp receptor agonist.the prostaglandin d2 (pgd2) receptors, members of g protein-coupled receptors, bind and are activated by prostaglandin d2. pgd2 receptors include the following proteins prostaglandin d2 receptor 1 (dp1) and prostaglandin d2 receptor 2 (dp2).
in vitro
bw 246c was found to be the less active c-8 diastereomer of the dp receptor agonist its analog bw 245c, having 70-fold less activity than that of bw 245c. for bw 245c, a significant species variation was observed in the anti-aggregatory potency so that it was about one hundred times more effective than in the human in the rat. however, the relative potencies of pgi2 and pge1 were found to be similar in both species. moreove, it was observed that in radioligand binding studies bw 245c had a high affinity and selectivity for pgd2 platelet receptors, and the binding to pgi2 or pge2 receptors was not found [1].
in vivo
animal study showed that, an intravenous bolus injection of 250 μg/kg bw 245c to spontaneously hypertensive rats was able to lower both systolic (-23%) and diastolic (-34%) blood pressure [1].
References
[1] town, m. h.,casals-stenzel, j. and schillinger, e. pharmacological and cardiovascular properties of a hydantoin derivative, bw 245 c, with high affinity and selectivity for pgd2 receptors. prostaglandins 25, 13-28 (1983).
Properties of (4R)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID
storage temp. | Store at -20°C |
solubility | ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide |
form | crystalline solid |
Safety information for (4R)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID
Computed Descriptors for (4R)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%View Details
99903-60-3 -
88491-46-7 98%View Details
88491-46-7 -
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%View Details
25408-95-1 -
2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%View Details
1805639-70-6 -
1784294-80-9 98%View Details
1784294-80-9 -
Lithium ClavulanateView Details
61177-44-4