4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
- CAS NO.：153436-22-7
- Empirical Formula: C18H12Cl2N2O3
- Molecular Weight: 375.21
- MDL number: MFCD00923984
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:34
![4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Structural](https://img.chemicalbook.in/CAS/GIF/153436-22-7.gif)
What is 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT?
The Uses of 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist).
Definition
ChEBI: 3-(3-anilino-3-oxoprop-1-enyl)-4,6-dichloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.
Biological Activity
Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .
Safety Profile
A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx and Cl-.
Properties of 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
| Melting point: | >270°C (dec.) |
| Boiling point: | 701.1±60.0 °C(Predicted) |
| Density | 1.561±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.77±0.30(Predicted) |
| color | Pale Yellow |
| Stability: | Hygroscopic |
Safety information for 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
Computed Descriptors for 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
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