4,5,6,7-TETRAHYDROINDOLE
Synonym(s):2,3-Tetramethylenepyrrole;Cyclohex[b]pyrrole;NSC 122455
- CAS NO.：13618-91-2
- Empirical Formula: C8H11N
- Molecular Weight: 121.18
- MDL number: MFCD00012134
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-30 16:20:48
What is 4,5,6,7-TETRAHYDROINDOLE?
The Uses of 4,5,6,7-TETRAHYDROINDOLE
4,5,6,7-Tetrahydroindole was used as reactant in:
- synthesis of ethyl 3-(4,5,6,7-tetrahydroindol-2-yl)-2-propynoate
- preparation of BODIPY dyes
- N-alkylation with chloromethyloxirane
- preparation of hydroindolepropynoate by chemo- and regioselective solvent-free ethynylation
- palladium- and copper-free cross-coupling of halopropynoates
- preparation of carbonylalkenyl indoles via coupling with dicarbonyl compounds
- 1:2 annelation of 4,5,6,7-tetrahydroindole with 1-benzoyl-2-phenylacetylene
The Uses of 4,5,6,7-TETRAHYDROINDOLE
4,5,6,7-Tetrahydro-1H-indole is used in preparation of chiral tetraaryl-substituted Methane. Also, used in preparation of 4-substituted Phenylamidine derivatives used for controlling phytopathogenic microorganisms.
General Description
4,5,6,7-Tetrahydroindoles, due to their easy aromatization, are good intermediates to synthesize indoles. 4,5,6,7-Tetrahydroindole on condensation with cyanoacetate leads to 1-ethylthio-2-cyano-4,5,6,7-tetrahydrocyclohexa-[c]-3H-pyrrolizin-3-one.
Properties of 4,5,6,7-TETRAHYDROINDOLE
| Melting point: | 53-57 °C(lit.) |
| Boiling point: | 64 °C(Press: 0.1 Torr) |
| Density | 1.057±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 18.03±0.20(Predicted) |
| BRN | 108853 |
Safety information for 4,5,6,7-TETRAHYDROINDOLE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4,5,6,7-TETRAHYDROINDOLE
| InChIKey | KQBVVLOYXDVATK-UHFFFAOYSA-N |
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