1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE

Synonym(s):4,5,6,7-Tetrahydro-4-oxoindole;NSC 131681

CAS NO.：13754-86-4
Empirical Formula: C8H9NO
Molecular Weight: 135.16
MDL number: MFCD00075438
SAFETY DATA SHEET (SDS)
Update Date: 2023-11-08 17:00:29

1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE Structural

What is 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE?

The Uses of 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE

1,5,6,7-Tetrahydro-4H-indol-4-one, is a versatile building block used for the synthesis of more complex pharmaceutical compounds. It can be used for the preparation of Psammopemmin A.

The Uses of 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE

• ;Reactant in synthesis of psammopemmin A as antitumor agent1• ;Reactant in synthesis of a 1,3,4,5-tetrahydrobenzindole β-ketoesters and tricyclic tetrahydrobenzindoles via C-H insertion reactions2• ;Reactant in preparation of tricyclic indole and dihydroindole derivatives as inhibitors of guanylate cyclase3• ;Reactant in preparation of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of (halobenzyl)pyrroles4• ;Reactant in enantioselective preparation of arylalkenyl indoles via asymmetric C-H insertion of rhodium carbenoids foll

General Description

Iodination of 1,5,6,7-tetrahydro-4H-indol-4-one using 1-chloromethyl--4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetra-fluoroborate) yields α-iodo derivative as the main product.

Properties of 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE

Melting point:	188-190 °C (lit.)
Boiling point:	311℃
Density	1.216
Flash point:	150℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	powder to crystal
pka	15.91±0.20(Predicted)
color	White to Light yellow to Light orange
CAS DataBase Reference	13754-86-4(CAS DataBase Reference)

Safety information for 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.