4,5-Dimethoxy-1-cyanobenzocyclobutane

CAS NO.：35202-54-1
Empirical Formula: C11H11NO2
Molecular Weight: 189.21
MDL number: MFCD01846132
EINECS: 609-091-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-17 21:30:02

What is 4,5-Dimethoxy-1-cyanobenzocyclobutane?

The Uses of 4,5-Dimethoxy-1-cyanobenzocyclobutane

4,5-Dimethoxy-1-cyanobenzocyclobutane is used in the preparation of selective bradycardic agents.

The Uses of 4,5-Dimethoxy-1-cyanobenzocyclobutane

4,5-Dimethoxy-1-benzocyclobutenecarbonitrile is used in the preparation of selective bradycardic agents.

Synthesis

NaNH2 (39.0 g, 1.0 mol) was added in portions to a solution of hydrocinnamonitrile 8 (224.0 g, 0.83 mol) in liquid ammonia at -45°C, and the reaction mixture was stirred at -45 °C for 2 h. After evaporation of the excess NH3, NH4Cl (20.0 g) and water (1000 mL) were added in portions. After standing at room temperature, greyish crystals separated and were collected and recrystallised with ethanol to give 4,5-Dimethoxy-1-cyanobenzocyclobutane as a colourless powder. Yield 116.5 g (74%).

Properties of 4,5-Dimethoxy-1-cyanobenzocyclobutane

Melting point:	83-84 °C
Boiling point:	345.9±42.0 °C(Predicted)
Density	1.18
vapor pressure	0.004Pa at 25℃
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol
form	Solid
color	Light Brown
CAS DataBase Reference	35202-54-1(CAS DataBase Reference)

Safety information for 4,5-Dimethoxy-1-cyanobenzocyclobutane

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.