4,4,4-Trifluoro-3-oxobutanenitrile

CAS NO.：110234-68-9
Empirical Formula: C4H2F3NO
Molecular Weight: 137.06
MDL number: MFCD11099951
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-30 16:20:48

What is 4,4,4-Trifluoro-3-oxobutanenitrile?

The Uses of 4,4,4-Trifluoro-3-oxobutanenitrile

4,4,4-Trifluoro-3-oxobutanenitrile (cas# 110234-68-9) is used as a reagent in the preparation of ((dimethoxyquinazolinyloxy)phenyl)urea derivatives as orally efficacious inhibitors of V-RAF murine sarcoma viral oncogene. Additionally, it is used as a reagent in preparation of orally active inhibitors of Brahma homolog (BRM)/SMARCA2 ATPase activity for treatment of Brahma related gene 1 (BRG1)/SMARCA4-mutant cancers. It is also used as a reagent in the synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from fluorinated precursors.

Properties of 4,4,4-Trifluoro-3-oxobutanenitrile

Boiling point:	43 °C(Press: 2.5 Torr)
Density	1.350±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
pka	2.74±0.10(Predicted)

Safety information for 4,4,4-Trifluoro-3-oxobutanenitrile

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H225:Flammable liquids H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.