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HomeProduct name list4-Vinylpyridine

4-Vinylpyridine

  • CAS NO.:100-43-6
  • Empirical Formula: C7H7N
  • Molecular Weight: 105.14
  • MDL number: MFCD00006447
  • EINECS: 202-852-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
4-Vinylpyridine Structural

What is 4-Vinylpyridine?

Description

4-vinylpyridine (4VP) is a pyridine derivative with a vinyl group in the 4-position. It is a colorless liquid, although impure samples are often brown. This compound belongs to a class of polar vinyl monomers that are important in many applications due to the ability of their polymers to form complexes of the electron-rich pyridine ring and to form polyelectrolytes through protonation or quaternization with alkyl or aryl halides. 4VP is sometimes used in biochemistry to alkylate protein cysteine residues. When compared to other alkylation agents, such as iodoacetamide, acrylamide, and N-ethylmaleimide, 4VP is less reactive, meaning the completion rate of cysteine alkylation is lower, but it also yields fewer side reactions[1].

Chemical properties

dark brown to yellow liquid. 2.9g can be dissolved in 100g of water at 20℃, soluble in methanol, ether, benzene, acetone, and slightly soluble in ether. When exposed to light and heat, polymerization occurs, and 0.1%-0.2% hydroquinone is often added as a polymerization inhibitor during storage.

The Uses of 4-Vinylpyridine

4-Vinylpyridine acts as a co-monomer in styrene-butadiene polymers to promote adhesion between the rubber compound and supporting fibers (or cords) in tires, belts and hoses. It serves as an intermediate for manufacturing chemicals and pharmaceuticals. Further, it is used as a reagent for the modification of cysteine. In addition to this, it is used to make poly(4-vinylpyridine) and elastomers.

What are the applications of Application

4-Vinylpyridine was used as a monomer in polymer chemistry and induced nonimmunological contact urticaria and allergic contact dermatitis. No crossreactivity is observed between pyridine derivatives. It can be copolymerized with many other monomers, in particular cationic monomers, such as acrylamide, acrylates, and also with other vinyl-based monomers (e.g. styrene).?

Preparation

4-Vinylpyridine is synthesized by reacting 4-picoline with formaldehyde to generate 4-pyridineethanol, which is then dehydrated.

Flammability and Explosibility

Flammable

Purification Methods

6 2 . Purify the monomer by fractional distillation under a good vacuum and in a N2 atmosphere and store it in sealed ampoules under N2, and keep it in the dark at -20o. The picrate has m 175-176o. [UV: Coleman & Fuoss J Am Chem Soc 77 5472 1955, Overberger et al. J Polymer Sci 27 381 1958, Petro & Smyth J Am Chem Soc 79 6142 1957.] It is used for alkylating SH groups in peptides [Anderson & Friedman Can J Biochem 49 1042 1971, Cawins & Friedman Anal Biochem 35 489 1970]. [Beilstein 20 II 170, 20 III/IV 2887, 20/6 V 213.]

References

[1] Baskaran, D. and A. Müller. “Anionic Polymerization of Polar Vinyl Monomers.” (2012): 623-655

Properties of 4-Vinylpyridine

Melting point: <25 °C
Boiling point: 62-65 °C/15 mmHg (lit.)
Density  0.975 g/mL at 25 °C (lit.)
vapor pressure  2.28hPa at 25℃
refractive index  n20/D 1.549(lit.)
Flash point: 125 °F
storage temp.  -20°C
solubility  Chloroform, Methanol (Slightly)
form  Liquid
pka pK1:5.62(+1) (25°C)
color  Clear colorless to yellow-brown
Water Solubility  29 G/L (20 ºC)
BRN  104506
Exposure limits ACGIH: TWA 1 mg/m3
OSHA: TWA 2 mg/m3
NIOSH: IDLH 50 mg/m3; Ceiling 2 mg/m3
Stability: Stable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference 100-43-6(CAS DataBase Reference)
NIST Chemistry Reference Pyridine, 4-ethenyl-(100-43-6)
EPA Substance Registry System 4-Vinylpyridine (100-43-6)

Safety information for 4-Vinylpyridine

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H226:Flammable liquids
H314:Skin corrosion/irritation
H317:Sensitisation, Skin
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Vinylpyridine

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