4-(Trifluoromethyl)benzophenone

CAS NO.：728-86-9
Empirical Formula: C14H9F3O
Molecular Weight: 250.22
MDL number: MFCD00000400
EINECS: 211-974-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 21:39:59

What is 4-(Trifluoromethyl)benzophenone?

Chemical properties

OFF-WHITE TO BEIGE CRYSTALLINE SOLID

Synthesis

A solution of diphenylmethanol (1 mmol), NBS (1.3equiv.), KOAc (1.5 equiv.) H2O (1.5 mL), and CH2Cl2 (0.5mL) was magnetically stirred in 25 mL flask at room temperaturefor 10 h. The reaction mixture was added into water(10 mL), and extracted with EtOAc (3 × 10 mL). The combinedEtOAc extracts were dried over anhydrous MgSO4,filtrated, and then the solvent was removed under reducedpressure. The residue was purified by the flash columnchromatography on silica gel with PE or PE/EtOAc as theeluent to obtain the desired product 4-(Trifluoromethyl)benzophenone.

Properties of 4-(Trifluoromethyl)benzophenone

Melting point:	114-116 °C(lit.)
Boiling point:	309.2±42.0 °C(Predicted)
Density	1.2778 (estimate)
storage temp.	Sealed in dry,Room Temperature
form	Crystalline Solid
color	Off-white to beige
BRN	1879572
InChI	InChI=1S/C14H9F3O/c15-14(16,17)12-8-6-11(7-9-12)13(18)10-4-2-1-3-5-10/h1-9H
CAS DataBase Reference	728-86-9(CAS DataBase Reference)

Safety information for 4-(Trifluoromethyl)benzophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.