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HomeProduct name list4-THIOURIDINE

4-THIOURIDINE

Synonym(s):RNA synthesis inhibitor

  • CAS NO.:13957-31-8
  • Empirical Formula: C9H12N2O5S
  • Molecular Weight: 260.27
  • MDL number: MFCD00006538
  • EINECS: 237-735-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-06 18:33:45
4-THIOURIDINE Structural

What is 4-THIOURIDINE?

Description

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.

The Uses of 4-THIOURIDINE

4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases.

The Uses of 4-THIOURIDINE

Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.

The Uses of 4-THIOURIDINE

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

What are the applications of Application

4-Thiouridine is a photoreactive thionucleobase and ribonucleotide analog used as an antisense agent.

Definition

ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.

General Description

4-Thiouridine is a photoreactive uridine analog.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

storage

Store at -20°C

Properties of 4-THIOURIDINE

Melting point: 139-140℃ (ethanol )
Density  1.72±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO (Slightly), Methanol (Slightly, Sonicated)
form  crystalline
pka 4.75±0.20(Predicted)
color  light yellow
Water Solubility  Soluble in water (20 mg/ml), and methanol (10 mg/ml).
CAS DataBase Reference 13957-31-8(CAS DataBase Reference)

Safety information for 4-THIOURIDINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-THIOURIDINE

InChIKey ZLOIGESWDJYCTF-XVFCMESISA-N

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