4-THIOURIDINE
Synonym(s):RNA synthesis inhibitor
- CAS NO.:13957-31-8
- Empirical Formula: C9H12N2O5S
- Molecular Weight: 260.27
- MDL number: MFCD00006538
- EINECS: 237-735-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 18:33:45
What is 4-THIOURIDINE?
Description
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.
The Uses of 4-THIOURIDINE
4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases.
The Uses of 4-THIOURIDINE
Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.
The Uses of 4-THIOURIDINE
4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.
What are the applications of Application
4-Thiouridine is a photoreactive thionucleobase and ribonucleotide analog used as an antisense agent.
Definition
ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.
General Description
4-Thiouridine is a photoreactive uridine analog.
Biochem/physiol Actions
4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.
storage
Store at -20°C
Properties of 4-THIOURIDINE
Melting point: | 139-140℃ (ethanol ) |
Density | 1.72±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
form | crystalline |
pka | 4.75±0.20(Predicted) |
color | light yellow |
Water Solubility | Soluble in water (20 mg/ml), and methanol (10 mg/ml). |
CAS DataBase Reference | 13957-31-8(CAS DataBase Reference) |
Safety information for 4-THIOURIDINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-THIOURIDINE
InChIKey | ZLOIGESWDJYCTF-XVFCMESISA-N |
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