4-THIOURACIL
Synonym(s):2-Hydroxy-4-mercaptopyrimidine
- CAS NO.:591-28-6
- Empirical Formula: C4H4N2OS
- Molecular Weight: 128.15
- MDL number: MFCD00090842
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is 4-THIOURACIL?
Description
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm. 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.
Chemical properties
yellow powder
The Uses of 4-THIOURACIL
4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.
The Uses of 4-THIOURACIL
4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.
What are the applications of Application
4-Thiouracil is a compound used in biosynthetic tagging in RNA analysis
Synthesis Reference(s)
Synthesis, p. 256, 1987 DOI: 10.1055/s-1987-27906
Properties of 4-THIOURACIL
Melting point: | 295 °C (dec.) (lit.) |
Density | 1.368 (estimate) |
refractive index | 1.7000 (estimate) |
storage temp. | Store at -20°C |
solubility | 1 M NaOH: soluble50mg/mL |
form | Powder |
pka | 5.38±0.20(Predicted) |
color | Yellow |
CAS DataBase Reference | 591-28-6(CAS DataBase Reference) |
Safety information for 4-THIOURACIL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for 4-THIOURACIL
New Products
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