4'-tert-Butylacetophenone

Synonym(s):1-[4-(1,1-Dimethylethyl)phenyl]ethanone

clear colorless liquid

4'-tert-Butylacetophenone is used in the synthesis of 2-pyridone derivatives.

4-tert-Butylacetophenone is an Impurity arising in the synthesis of Ebastine (E320000). Ebastine Impurity B.

4′-tert-Butylacetophenone may be used in the synthesis of 2-pyridone derivatives and their fluorescence spectra has been evaluated.

4′-tert-Butylacetophenone is a para-substituted acetophenone.

Melting point:	17-18 °C (dimorphic)(lit.)
Boiling point:	107-108 °C5 mm Hg(lit.)
Density	0.964 g/mL at 25 °C(lit.)
refractive index	n20/D 1.52(lit.)
Flash point:	86 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Liquid
color	Clear colorless
Specific Gravity	0.964
Water Solubility	insoluble
CAS DataBase Reference	943-27-1(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-[4-(1,1-dimethylethyl)phenyl]-(943-27-1)
EPA Substance Registry System	Ethanone, 1-[4-(1,1-dimethylethyl)phenyl]- (943-27-1)

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P363:Wash contaminated clothing before reuse. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed.