4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID

CAS NO.：56671-28-4
Empirical Formula: C9H8O4
Molecular Weight: 180.16
MDL number: MFCD00052170
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:40

What is 4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID?

Chemical properties

White needle crystals. Melting point 141℃.

The Uses of 4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID

4-Oxo-4,5,6,7-tetrahydrobenzo[b]furan-3-carboxylic acid can be used as an intermediate of Propala.

Definition

ChEBI: 4-oxo-4,5,6,7-tetrahydrobenzo[b]furan-3-carboxylic acid is a member of benzofurans.

Synthesis

The methanol solution of resorcinol and potassium hydroxide is used to react with hydrogen under the action of active nickel to generate potassium 3-ketocyclohex-1-enolate, which is then cyclized with ethyl bromopyruvate under alkaline conditions , and then acidified to obtain ?4-oxo-4,5,6,7-tetrahydrobenzo[b]furan-3-carboxylic acid.

Properties of 4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID

Melting point:	140 °C
Boiling point:	383.5±42.0 °C(Predicted)
Density	1.406±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	3.74±0.20(Predicted)
CAS DataBase Reference	56671-28-4

Safety information for 4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.