4-Nitrobiphenyl

Chemical properties

Yellow Solid

Chemical properties

4-Nitrobiphenyl exists as yellow plates or needles..

The Uses of 4-Nitrobiphenyl

4-Nitrobiphenyl has some uses as a plasticizer, fungicide, and wood preservative.

The Uses of 4-Nitrobiphenyl

Formerly in preparation of p-biphenylamine, q.v.

The Uses of 4-Nitrobiphenyl

Formerly used as an intermediate for 4-aminobiphenyl

Background

Pnb has been used in trials studying the treatment of Pelvic Organ Prolapse.

Definition

ChEBI: 4-Nitrobiphenyl is a member of biphenyls.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 4499, 1996 DOI: 10.1016/0040-4039(96)00924-0

General Description

White to yellow needle-like crystalline solid with a sweetish odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Nitrobiphenyl is incompatible with the following: Strong reducers .

Hazard

Toxic by ingestion and skin contact. Confirmed carcinogen.

Health Hazard

p-Nitrobiphenyl (PNB) is a urinary bladder carcinogen in dogs.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

Potential Exposure

4-Nitrobiphenyl was formerly used in the synthesis of 4-aminodiphenyl. It is presently used only for research purposes; there are no commercial uses.

Carcinogenicity

The case for the carcinogenicity of PNB is supported by (1) the induction of urinary bladder cancer in dogs after administration of PNB; (2) the evidence that PNB is metabolized in vivo to 4-aminobiphenyl (a potent carcinogen); and (3) the possibility that the cases of human urinary bladder cancer attributed to 4- aminobiphenyl may also have been induced by exposure to PNB.1

Metabolism

Not Available

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with strong reducing agents such as hydrides, oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Incineration @ 982℃/2.0 seconds (minimum) with scrubbing for nitrogen oxides abatement.