4-Nitrobenzyl bromide
Synonym(s):α-Bromo-4-nitrotoluene
- CAS NO.:100-11-8
- Empirical Formula: C7H6BrNO2
- Molecular Weight: 216.03
- MDL number: MFCD00007373
- EINECS: 202-820-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:11
What is 4-Nitrobenzyl bromide?
Chemical properties
white to light yellow crystal powde
The Uses of 4-Nitrobenzyl bromide
4-Nitrobenzyl bromide is used in the synthesis of di and tri-substituted azoles. It is also used in the preparation of N6-Benzyladenosine-5?-uronamides as selective A3 adenosine agonists.
Definition
ChEBI: A C-nitro compound that consists of nitrobenzene bearing a bromomethyl substituent at the para-position.
Purification Methods
Recrystallise the bromide four times from absolute EtOH, then twice from cyclohexane/hexane/*benzene (1:1:1), followed by sublimation at 0.1mm and final recrystallisation from the same solvent mixture. [Lichtin & Rao J Am Chem Soc 83 2417 1961.] It has also been crystallised from pet ether (b 80-100o, 10mL/g, charcoal). It slowly decomposes even when stored in a desiccator in the dark. IRRITANT. [Beilstein 5 IV 861.]
Properties of 4-Nitrobenzyl bromide
Melting point: | 98 °C |
Boiling point: | 265.51°C (rough estimate) |
Density | 1.6841 (rough estimate) |
refractive index | 1.6120 (estimate) |
storage temp. | Store at RT. |
solubility | soluble in Chloroform, Ethyl Acetate |
form | Crystalline Powder |
color | Light yellow to beige |
Water Solubility | It hydrolyzes in water. Soluble in alcohol and ether. |
BRN | 742796 |
Stability: | Stable. Incomaptible with bases, amines, oxidizing agents, alcohols. May be moisture sensitive. Corrodes steel. |
CAS DataBase Reference | 100-11-8(CAS DataBase Reference) |
NIST Chemistry Reference | Benzene, 1-(bromomethyl)-4-nitro-(100-11-8) |
EPA Substance Registry System | Benzene, 1-(bromomethyl)-4-nitro- (100-11-8) |
Safety information for 4-Nitrobenzyl bromide
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Nitrobenzyl bromide
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New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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