4-Morpholinecarbonyl chloride
- CAS NO.:15159-40-7
- Empirical Formula: C5H8ClNO2
- Molecular Weight: 149.58
- MDL number: MFCD00037053
- EINECS: 239-213-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-02-23 09:13:43
What is 4-Morpholinecarbonyl chloride?
The Uses of 4-Morpholinecarbonyl chloride
4-Morpholinecarbonyl chloride may be used in the preparation of a versatile fluorogenic label for biomolecular imaging. It may be used in the synthesis of:
- morpholine-4-carboxylic acid [4-(2,4-dimethylphenyl)thiazol-2-yl]amide
- morpholine-4-carboxylic acid [4-(2,4,6-trimethylphenyl)thiazol-2-yl]amide
- 2-isopropyl-6-methylpyrimidin-4-yl morpholine-4-carboxylate
The Uses of 4-Morpholinecarbonyl chloride
Photographic intermediate
What are the applications of Application
4-Morpholinecarbonyl chloride is A photographic intermediate
General Description
4-Morpholinecarbonyl chloride is a photographic intermediate. Rates of solvolysis of 4-morpholinecarbonyl chloride with N-alkyl group in aqueous binary solvents of acetone, ethanol, methanol, methanol-d, 2,2,2-trifluoroethanol, pure water and D2O has been determined. Preparation of 4-morpholinecarbonyl chloride has been reported.
Synthesis
4-Morpholinecarbonyl chloride is prepared by reacting morpholine hydrochloride with phosgene in an inert liquid medium such as toluene and xylene, at 50W150°C, pref. 60W120°C. The morpholine hydrochloride is prepared by dissolving 1 part by weight of morpholine in ≥4 parts of an inert liquid medium and introducing a slightly excessive HCl into the solution under agitation.
Properties of 4-Morpholinecarbonyl chloride
Boiling point: | 137-138 °C/33 mmHg (lit.) |
Density | 1.282 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Inert atmosphere,2-8°C |
form | clear liquid |
pka | -2.16±0.20(Predicted) |
color | Colorless to Light yellow |
BRN | 116257 |
InChI | InChI=1S/C5H8ClNO2/c6-5(8)7-1-3-9-4-2-7/h1-4H2 |
CAS DataBase Reference | 15159-40-7(CAS DataBase Reference) |
EPA Substance Registry System | 4-Morpholinecarbonyl chloride (15159-40-7) |
Safety information for 4-Morpholinecarbonyl chloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H351:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 4-Morpholinecarbonyl chloride
InChIKey | XMWFMEYDRNJSOO-UHFFFAOYSA-N |
SMILES | C(Cl)(N1CCOCC1)=O |
New Products
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