4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT
Synonym(s):Potassium 4-methylumbelliferyl sulfate
- CAS NO.:15220-11-8
- Empirical Formula: C10H9KO6S
- Molecular Weight: 296.33
- MDL number: MFCD00016970
- EINECS: 239-272-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-12 23:00:59
What is 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT?
Chemical properties
Crystalline Solid
The Uses of 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT
Met-enkephalin analog found in opioid extracts of brain and adrenal chromaffin cells that is an artifact generated by trichloroacetic acid extraction. MUS is used as a fluorimetric substrate for arylsulphatase enzyme. Subsitution of the hydroxyl group of 4-Methylumbelliferyl sulfate potassium salt causes the excitation wavelength of the umbelliferone to shift to shorter values and also brings about a decrease in fluorescence. Fluorescence: max. Abs = 334 mm; max. Em. = 370 mm
The Uses of 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT
4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.
Properties of 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT
Melting point: | 287-290°C |
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | Powder |
color | White to Pale Yellow |
Water Solubility | Soluble in water at 5mg/ml |
BRN | 3803203 |
Stability: | Stable in unbuffered solution for several months at -20° |
CAS DataBase Reference | 15220-11-8(CAS DataBase Reference) |
EPA Substance Registry System | 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt (15220-11-8) |
Safety information for 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT
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