4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
Synonym(s):4-Methylumbelliferyl α-D -glucoside;4-Methylumbelliferyl-α-D-glucopyranoside - CAS 17833-43-1 - Calbiochem;4-MU-α-D-Glc
- CAS NO.:17833-43-1
- Empirical Formula: C16H18O8
- Molecular Weight: 338.31
- MDL number: MFCD00067661
- EINECS: 241-794-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:34
What is 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE?
Description
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase. 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.
Chemical properties
white to off-white crystalline powder
The Uses of 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate in the assay of a-glucosidase,it has been used in the study of Pompe disease.
The Uses of 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s).
What are the applications of Application
4-Methylumbelliferyl α-D-glucopyranoside is a fluorogenic β-glucosidase substrate
Definition
ChEBI: 4-Methylumbelliferyl-alpha-D-glucopyranoside is a member of coumarins and a glycoside.
Purification Methods
Recrystallise 4-methylumbellifer-7-yl--D-glucopyranoside from hot H2O or EtOH. [Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 IV 443.]
Properties of 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
Melting point: | 171-173 °C |
Boiling point: | 626.9±55.0 °C(Predicted) |
Density | 1.522±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: 50 mg/mL, clear, colorless to faintly yellow |
form | White solid |
pka | 12.73±0.70(Predicted) |
color | White to Off-White |
BRN | 1690776 |
CAS DataBase Reference | 17833-43-1(CAS DataBase Reference) |
Safety information for 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
InChIKey | YUDPTGPSBJVHCN-JZYAIQKZSA-N |
New Products
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