4-Methylsulphonylphenylacetic acid
- CAS NO.:90536-66-6
- Empirical Formula: C9H10O4S
- Molecular Weight: 214.24
- MDL number: MFCD00216495
- EINECS: 618-577-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 4-Methylsulphonylphenylacetic acid?
Chemical properties
yellow to beige-brown crystalline powder
The Uses of 4-Methylsulphonylphenylacetic acid
4-(Methylsulfonyl)phenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Preparation
synthesis of 4-(Methylsulfonyl)phenylacetic acid: 1-(4-Methanesulfonyl-phenyl)-ethanone (20 mmol), morpholine (60 mmol) and elemental sulfur (40 mmol) were added in a round-bottom flask and refluxed for 2 h at 398 K. A 3N solution of NaOH (20 ml) was then added, and the reaction mixture refluxed for an additional 30 min. After cooling, the mixture was filtered and the filtrate was acidified with HCl to pH 6. The solution was again filtered off and washed with ethyl acetate. The resulting aqueous fraction was finally acidified with diluted HCl, to yield the pure product as a white solid. Crystals suitable for X-ray analysis were obtained by slow evaporation of an ethanol/water (1:1 v/v) solution.
What are the applications of Application
4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.
Properties of 4-Methylsulphonylphenylacetic acid
Melting point: | 136-140 °C(lit.) |
Boiling point: | 324.37°C (rough estimate) |
Density | 1.4230 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 3.90±0.10(Predicted) |
form | Solid |
color | White to Pale Yellow |
Water Solubility | slight |
BRN | 2646649 |
CAS DataBase Reference | 90536-66-6(CAS DataBase Reference) |
Safety information for 4-Methylsulphonylphenylacetic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Methylsulphonylphenylacetic acid
Abamectin manufacturer
Vepan Pharmatech Pvt Ltd
Venture Pharmaceuticals pvt ltd
Lakshmi Farmachem
Amogh Chemicals Pvt Ltd
Glyra Health Care Pvt Ltd
Navone Specialties (OPC) Pvt Ltd
Festiva Pharma
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
4-(Methylsulfonyl)phenylacetic acid 98%View Details
90536-66-6 -
90536-66-6 2-(4-(methylsulfonyl)phenyl)acetic acid 98%View Details
90536-66-6 -
4-Methylsulfonylphenylacetic acid 98%View Details
-
4-Methylsulfonylphenylacetic acid 98%View Details
90536-66-6 -
4-Methylsulfonylphenylacetic acid 98%View Details
-
4-Methylsulfonylphenylacetic acid 98%View Details
-
4-(Methylsulfonyl)phenylacetic acid CAS 90536-66-6View Details
90536-66-6 -
4-(Methylsulfonyl)phenylacetic Acid CAS 90536-66-6View Details
90536-66-6