4-(Methylsulfonyl)phenol
Synonym(s):4-Hydroxyphenyl methyl sulfone
- CAS NO.：14763-60-1
- Empirical Formula: C7H8O3S
- Molecular Weight: 172.2
- MDL number: MFCD00047806
- EINECS: 632-596-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-18 18:48:51
What is 4-(Methylsulfonyl)phenol?
Chemical properties
Tan to pink-brown powder
The Uses of 4-(Methylsulfonyl)phenol
4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
Reactions
The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).
Properties of 4-(Methylsulfonyl)phenol
| Melting point: | 90-95 °C |
| Boiling point: | 272.52°C (rough estimate) |
| Density | 1.3692 (rough estimate) |
| RTECS | SM1530000 |
| refractive index | 1.5151 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol |
| form | Powder |
| pka | pK1:7.83 (25°C) |
| color | Tan to pink-brown |
| Water Solubility | slight |
| BRN | 1866322 |
| CAS DataBase Reference | 14763-60-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-(Methylsulfonyl)phenol(14763-60-1) |
Safety information for 4-(Methylsulfonyl)phenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H303:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(Methylsulfonyl)phenol
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