4-(METHYLAMINO)-3-NITROBENZOIC ACID

CAS NO.：41263-74-5
Empirical Formula: C8H8N2O4
Molecular Weight: 196.16
MDL number: MFCD00464322
EINECS: 609-904-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

What is 4-(METHYLAMINO)-3-NITROBENZOIC ACID?

Chemical properties

Yellow Solid

The Uses of 4-(METHYLAMINO)-3-NITROBENZOIC ACID

4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.

Synthesis

Methyl 4-(methylamino)-3-nitrobenzoate (1.82 g, 8.66 mmol) was dissolved in a 1: 1 ratio of tetrahydrofuran (THF) (41.4 mL) and water (41.4 mL). Lithium hydroxide (1.817 g, 43.3 mmol) was added, and the reaction was stirred at rt for 16 h. The reaction mixture was cooled to 0 °C and acidified by the addition of 5M HC1 (-20 mL, until the pH reached -5) - a bright yellow precipitate formed, the slurry was filtered, and the residue washed with distilled H20 (2 x 30 mL). The residue was collected and dried in vacuo at 50 °C to afford the product as a yellow solid - 4-(methylamino)-3-nitrobenzoic acid (1.43 g, 7.29 mmol, 84 percent yield). This was used without further purification in the subsequent reactions.

Properties of 4-(METHYLAMINO)-3-NITROBENZOIC ACID

Melting point:	>300°C
Boiling point:	393.7±37.0 °C(Predicted)
Density	1.472±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO, Methanol
form	Solid
pka	4.28±0.10(Predicted)
color	Yellow
CAS DataBase Reference	41263-74-5

Safety information for 4-(METHYLAMINO)-3-NITROBENZOIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.