4-METHOXYPYRIDAZINE
- CAS NO.:20733-11-3
- Empirical Formula: C5H6N2O
- Molecular Weight: 110.11
- MDL number: MFCD08236840
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-27 16:27:43
What is 4-METHOXYPYRIDAZINE?
The Uses of 4-METHOXYPYRIDAZINE
4-methoxypyridazine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
The Uses of 4-METHOXYPYRIDAZINE
To a solution of 3 ,6-dichloro-4- methoxypyridazine (30 g, 167.59 mmol, 1.00 equiv) and ammonium formate (3 1 g, 491.63 mmol, 2.93 equiv) in MeOH (500 mL) was added 10% palladium on carbon (3 g) catalyst. The mixture was stirred under 1 atmosphere of at rt overnight. The catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was triturated in 500 mL of DCM MeOH ( 10: 1 ) and the solid material was filtered out. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (2:1 to 1: 1) to give 1 5 g (81%) of 4-methoxypyridazine as a brown oil. TLC: petroleum ether: ethyl acetate=2: 1 , Rf=0.1 .
Properties of 4-METHOXYPYRIDAZINE
Melting point: | 43-44℃ |
Boiling point: | 244℃ |
Density | 1.102 |
Flash point: | 89℃ |
storage temp. | Sealed in dry,Room Temperature |
pka | 4.28±0.10(Predicted) |
Safety information for 4-METHOXYPYRIDAZINE
Computed Descriptors for 4-METHOXYPYRIDAZINE
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