4-Isopropylphenol

Synonym(s):p-Cumenol

CAS NO.：99-89-8
Empirical Formula: C9H12O
Molecular Weight: 136.19
MDL number: MFCD00002372
EINECS: 202-798-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-27 14:35:30

What is 4-Isopropylphenol?

Chemical properties

WHITE TO BEIGE CRYSTALLINE SOLID

The Uses of 4-Isopropylphenol

4-Isopropylphenol is an Impurity of Propofol (P829750).

The Uses of 4-Isopropylphenol

4-Isopropylphenol was used in the synthesis of vinyl compounds. It is used as a flavor & fragrance agent in cosmetics.

Definition

ChEBI: 4-isopropylphenol is a member of the class of phenols that is phenol which is carrying an isopropyl group at position 4. It has a role as a flavouring agent. It derives from a hydride of a cumene.

Production Methods

4-Isopropylphenol is produced:
1) by isolation from Eucalyptus polybractea oil.
2) from Magnesium para-iso-propylphenyl-bromide by air oxidation.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3889, 1949 DOI: 10.1021/ja01180a005
Synthesis, p. 396, 1978 DOI: 10.1055/s-1978-24762

General Description

Sonochemical degradation of 4-Isopropylphenol has been studied.

Properties of 4-Isopropylphenol

Melting point:	59-61 °C (lit.)
Boiling point:	212-213 °C (lit.)
Density	0.9900
vapor density	>1 (vs air)
refractive index	1.5228
Flash point:	108°C
storage temp.	Store at +2°C to +8°C.
solubility	Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
pka	10.19±0.13(Predicted)
form	Crystalline Mass or Crystals
color	White to beige-brown
Odor	at 1.00 % in dipropylene glycol. woody warm spicy medicinal
Water Solubility	Slightly soluble in water, soluble in ethanol and ethyl ether.
BRN	1363564
CAS DataBase Reference	99-89-8(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 4-(1-methylethyl)-(99-89-8)
EPA Substance Registry System	p-Isopropylphenol (99-89-8)

Safety information for 4-Isopropylphenol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.