4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- CAS NO.:1421312-34-6
- Empirical Formula: C18H15NO4
- Molecular Weight: 309.32
- MDL number: MFCD30489347
- Update Date: 2023-12-21 13:02:20
![4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Structural](https://img.chemicalbook.in/CAS/20180808/GIF/1421312-34-6.gif)
What is 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester?
The Uses of 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.
Preparation
Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution. Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).
Properties of 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Boiling point: | 537.3±45.0 °C(Predicted) |
Density | 1.289±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere, 2-8°C |
pka | 6.24±0.50(Predicted) |
Safety information for 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Computed Descriptors for 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Abamectin manufacturer
CHEMAZON LABORATORIES PRIVATE LIMITED
MANVI BIOPHARMA PVT LTD,
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