4-Fluorophenylacetylene

CAS NO.：766-98-3
Empirical Formula: C8H5F
Molecular Weight: 120.12
MDL number: MFCD00168823
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-26 11:30:52

What is 4-Fluorophenylacetylene?

Chemical properties

White Crystalline Solid

The Uses of 4-Fluorophenylacetylene

Intermediates of liquid Crystals. As pharmaceutical intermediates. As organic synthesis intermediates. For vacuum deposition.

The Uses of 4-Fluorophenylacetylene

Intermediates of Liquid Crystals

The Uses of 4-Fluorophenylacetylene

1-Ethynyl-4-fluorobenzene, a substituted phenylacetylene, may be used in the synthesis of aryl acetylenes, via Sonogashira type cross coupling reaction with various haloarenes in the presence of bis(μ-iodo)bis((-)-sparteine)dicopper(I) catalyst.

Synthesis Reference(s)

Synthesis, p. 589, 1996 DOI: 10.1055/s-1996-4265

General Description

1-Ethynyl-4-fluorobenzene (pFAB) is a fluorobenzene derivative. Trianionic pincer alkylidyne complex catalyzed polymerization of 1-ethynyl-4-fluorobenzene has been reported. The surface of the iodophenyl-terminated organic monolayers has been modified by Sonogashira coupling of the iodophenyl groups found on the surface with pFAB. Dimerization catalyzed by Y[N(TMS)₂]₃ and 4-chloroaniline gave exclusive formation of one of three possible enediynes in excellent yield.

Properties of 4-Fluorophenylacetylene

Melting point:	26-27 °C(lit.)
Boiling point:	55-56 °C40 mm Hg(lit.)
Density	1.048 g/mL at 25 °C(lit.)
refractive index	n20/D 1.516(lit.)
Flash point:	29 °C
storage temp.	2-8°C
solubility	soluble in Chloroform, Diethyl Ether, Ethanol
form	Liquid After Melting
color	Clear colorless to yellow
Specific Gravity	1.048
Water Solubility	Soluble in chloroform, diethyl ether, acetone, dichloromethane, hexane and ethanol. Highly soluble in toluene. Insoluble in water.
BRN	1099285
CAS DataBase Reference	766-98-3(CAS DataBase Reference)
NIST Chemistry Reference	4-FC6H4CCH(766-98-3)

Safety information for 4-Fluorophenylacetylene

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H228:Flammable solids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.