4-Fluorophenylacetonitrile

Synonym(s):4-Fluorobenzyl cyanide

CAS NO.：459-22-3
Empirical Formula: C8H6FN
Molecular Weight: 135.14
MDL number: MFCD00001917
EINECS: 207-286-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is 4-Fluorophenylacetonitrile?

Chemical properties

Clear light yellow liquid

The Uses of 4-Fluorophenylacetonitrile

4-Fluorophenylacetonitrile is used as a reagent in the synthesis of novel Daidzein analogs which exhibit anti-influenza activity in vitro. It is also used as a reagent in the synthesis of benzylbenzo[d]thiazole sulfonamides which exhibit anti-inflammatory activity.

General Description

4-Fluorophenylacetonitrile is starting reagent in the synthesis of 1-Alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives.

Biochem/physiol Actions

4-Fluorophenylacetonitrile undergoes biotransformation to 4-Fluorophenylacetic acid by marine fungi, Aspergillus sydowii Ce19.

Properties of 4-Fluorophenylacetonitrile

Melting point:	86°C
Boiling point:	119-120 °C/18 mmHg (lit.)
Density	1.126 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5002(lit.)
Flash point:	227 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
color	Clear colorless to light yellow
BRN	1907764
Exposure limits	NIOSH: IDLH 25 mg/m3
CAS DataBase Reference	459-22-3(CAS DataBase Reference)
NIST Chemistry Reference	4-Fluorophenylacetic acid nitrile(459-22-3)
EPA Substance Registry System	Benzeneacetonitrile, 4-fluoro- (459-22-3)

Safety information for 4-Fluorophenylacetonitrile

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.