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HomeProduct name list4-Ethylresorcinol

4-Ethylresorcinol

Synonym(s):2,4-Dihydroxy-1-ethylbenzene

  • CAS NO.:2896-60-8
  • Empirical Formula: C8H10O2
  • Molecular Weight: 138.16
  • MDL number: MFCD00002283
  • EINECS: 220-777-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 13:37:16
4-Ethylresorcinol  Structural

What is 4-Ethylresorcinol ?

Description

4-Ethylresorcinol is a derivative of resorcinol, which acts as a substrate for tyrosinase. 4-Ethylresorcinol has hypopigmentation effects.4-Ethylresorcinol attenuates the mRNA and protein expression of tyrosinase-related protein (TRP)-2, and has an antioxidant effect through the inhibition of lipid peroxidation. 4-Ethylresorcinol is a derivative of resorcinol, which acts as a substrate for tyrosinase. 4-Ethylresorcinol is a derivative of resorcinol.

Chemical properties

slightly beige crystalline powder

The Uses of 4-Ethylresorcinol

It is employed as an active pharmaceutical intermediate.

Definition

ChEBI: 4-Ethylresorcinol is a member of resorcinols.

Synthesis Reference(s)

Synthetic Communications, 15, p. 1315, 1985 DOI: 10.1080/00397918508077280

Synthesis

The synthesis of 4-Ethylresorcinol is as follows:
In a three necked round bottom flask (equipped with a condensor, additional funnel and mechanical stirrer) was added 15.2 g of a combination of Raney Nickel and Ni supported on silica. (50: 50). 100 ml of a mixture of 50: 50 ethanol: water was added and the reaction was heated at reflux conditions. 15.2 g of 2,4-dihydroxy acetophenone in 100 ml of water: ethanol and 10 ml of acetic acid was placed in the additional funnel and slowly added to the mixture (dropwise). The reaction was filtered through a milipore filter to give a pale yellow solution. Concentration of this solution in vacuo gave a solid. This solid was crystalized from 1,2-dichloroethane to give 4-ethyl resorcinol in 80% isolated yield. 
synthesis of 4-Ethylresorcinol.png

Properties of 4-Ethylresorcinol

Melting point: 95-98 °C (lit.)
Boiling point: 155 °C / 10mmHg
Density  1.0742 (rough estimate)
refractive index  1.5231 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Solubility in methanol; almost transparency. Soluble in alcohol.
form  Crystalline Powder
pka 10.06±0.10(Predicted)
color  Slightly beige
BRN  1238231
CAS DataBase Reference 2896-60-8(CAS DataBase Reference)
NIST Chemistry Reference 1,3-Benzenediol, 4-ethyl-(2896-60-8)
EPA Substance Registry System 4-Ethylresorcinol (2896-60-8)

Safety information for 4-Ethylresorcinol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Ethylresorcinol

InChIKey VGMJYYDKPUPTID-UHFFFAOYSA-N

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