4-Dodecanolide
Synonym(s):(±)-γ-Octyl-γ-butyrolactone;(±)-4-Dodecanolide;(±)-Dihydro-5-octyl-2(3H)-furanone
- CAS NO.:2305-05-7
- Empirical Formula: C12H22O2
- Molecular Weight: 198.3
- MDL number: MFCD00036499
- EINECS: 218-971-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-26 17:49:17
What is 4-Dodecanolide ?
Chemical properties
γ-Dodecalactone has a fatty, peachy, somewhat musky odor and buttery, peach-like flavor
Occurrence
Reported found in apricot, cooked pork, milk products, peach, bilberry, guava fruit, papaya, pineapple, fresh blackberry, strawberry, celery leaves and stalks, celery root, blue cheeses, cheddar cheese, Swiss cheese, meats, beer, rum, mushrooms, plum brandy, quince, chervil, naranjilla fruit and other natural sources
The Uses of 4-Dodecanolide
4-Dodecanolide was one of the organic compounds from meat charbroiling operations studied.
Preparation
From 1-dodecen-12-oic acid with H2SO4 at 90°C; from 4-hydroxydodecanoic acid by lactonization; also from methylacrylate and octanol
Definition
ChEBI: Xi-Dihydro-5-octyl-2(3H)-furanone is a gamma-lactone.
Aroma threshold values
Detection: 7 ppb; aroma characteristics at 1.0%; sweet, creamy, fruity peach and apricot, lactonic, with dairy waxy and fatty nuances.
Taste threshold values
Taste characteristics at 1 to 10 ppm: sweet, fruity peach, milky fatty and waxy with a pulpy fruity mouthfeel.
Synthesis Reference(s)
Journal of the American Chemical Society, 108, p. 3745, 1986 DOI: 10.1021/ja00273a032
Organic Syntheses, Coll. Vol. 7, p. 400, 1990
Safety Profile
A skin irritant. When heated todecomposition it emits acrid smoke and irritating vapors
Properties of 4-Dodecanolide
Melting point: | 17-18 °C(lit.) |
Boiling point: | 130-132 °C1.5 mm Hg(lit.) |
Density | 0.936 g/mL at 25 °C(lit.) |
vapor pressure | 7.3hPa at 20℃ |
refractive index | n |
FEMA | 2400 | GAMMA-DODECALACTONE |
Flash point: | >230 °F |
storage temp. | Refrigerator, under inert atmosphere |
solubility | Chloroform (Sparingly), Methanol (Slightly) |
form | Oil |
color | Colourless |
Specific Gravity | 0.94 |
Odor | at 100.00 %. fatty peach sweet metallic fruity |
Water Solubility | 60mg/L at 20℃ |
JECFA Number | 235 |
BRN | 126680 |
CAS DataBase Reference | 2305-05-7(CAS DataBase Reference) |
NIST Chemistry Reference | «GAMMA» dodecalactone(2305-05-7) |
EPA Substance Registry System | 2(3H)-Furanone, dihydro-5-octyl- (2305-05-7) |
Safety information for 4-Dodecanolide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Dodecanolide
InChIKey | WGPCZPLRVAWXPW-UHFFFAOYSA-N |
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